Saccharomyces boulardii, Bacillus subtilis, Bacillus coagulans, and Bacillus clausii are normal inhabitants of the intestine, with no pathogenic powers. When administered orally, Saccharomyces boulardii, Bacillus subtilis, Bacillus coagulans, and Bacillus clausii spores cross the gastric juice barrier, reaching the intestinal tract unharmed, where they revive into metabolically active vegetative cells. The administration of these strains can support the recovery of intestinal microbial flora altered during microbial disorders of diverse origins. Bacillus subtilis can produce high levels of short-chain fatty acids such as butyrate, which, at the intestinal level, can support trans-epithelial fluid transport, promote the epithelial defense barrier, and support visceral sensitivity and intestinal motility modulation.
Additionally, these species demonstrate resilience in the presence of microbial disturbing medications, which can provide preventative therapeutic support for altered intestinal microbial flora. Due to their stability, Saccharomyces boulardii, Bacillus subtilis, Bacillus coagulans, and Bacillus clausii can be administered during certain medication therapy.